Description

Plasminogen CAS NO 9001-91-6 is a critical zymogen, or proenzyme, that is the inactive precursor to the serine protease plasmin. This protein plays a fundamental role in the fibrinolytic system, which is essential for breaking down blood clots and maintaining vascular patency. It is a vital raw material and research reagent for the pharmaceutical, diagnostic, and life science research industries, particularly in the development of thrombolytic therapies and hemostasis studies.

Application

• Pharmaceutical Active Ingredient: Serves as the starting material for the production of thrombolytic drugs used to treat conditions like acute ischemic stroke, pulmonary embolism, and deep vein thrombosis.
• Biomedical Research: Essential for in vitro and in vivo studies of the fibrinolytic system, angiogenesis, cell migration, and wound healing processes.
• Diagnostic Reagent Manufacturing: Used as a key component in clinical diagnostic kits and assays designed to measure plasminogen activity or antigen levels in human plasma, aiding in the diagnosis of thrombotic or bleeding disorders.
• Enzyme Biochemistry Studies: Employed to investigate enzyme kinetics, zymogen activation mechanisms, and serine protease inhibitor (serpin) interactions.
• Cell Culture & Tissue Engineering: Utilized in specialized media formulations to study cellular processes that require plasmin-mediated extracellular matrix remodeling.
• Reference Standard: Acts as a high-purity calibrant and quality control standard in laboratory settings and regulatory submissions.

Basic Information

Product Name	Plasminogen
CAS No.	9001-91-6
Molecular Formula	Contact for details
Molecular Weight	~90 kDa (Glu-plasminogen)
Synonyms	Plasminogen Human; Plasminogen Precursor; Fibrinolysin Precursor; Glu-Plasminogen; Lys-Plasminogen; Plasminogen Activator Substrate; Plasmin Proenzyme; EC 3.4.21.7 (precursor)
EINECS	Contact for details

Quality Control

Our Plasminogen is manufactured and tested under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and safety, meeting the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) detailing purity (by HPLC/SDS-PAGE), specific activity, sterility (where applicable), and endotoxin levels are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. For short-term use, it may be stored at 2-8°C for several days.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (SDS-PAGE / Immunoassay)	Conforms
Purity (HPLC / SDS-PAGE)	≥ 95%
Specific Activity	Contact for details
Protein Content (UV Absorbance / Bradford)	Contact for details
Endotoxin	< 1.0 EU/mg (for injectable grade)
Solubility	Soluble in water or appropriate buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.