Description

Penicillinase CAS NO 9001-74-5 is a highly specific β-lactamase enzyme that catalyzes the hydrolysis of the β-lactam ring in penicillin antibiotics, rendering them inactive. This precise enzymatic activity is critical for research, quality control, and diagnostic applications where the neutralization or detection of penicillin is required. It is an essential reagent for pharmaceutical manufacturers, clinical laboratories, and academic research institutions focused on antibiotic resistance, drug development, and microbiological testing.

Application

• Pharmaceutical Quality Control: Used to inactivate penicillin in sterility testing, microbial limit tests, and antibiotic potency assays to ensure accurate results.
• Clinical Diagnostics: Employed in diagnostic kits and assays to detect penicillin allergy or the presence of β-lactamase-producing bacteria.
• Antibiotic Resistance Research: A key tool for studying the mechanisms, kinetics, and inhibition of β-lactamase enzymes.
• Food Safety Testing: Applied in methods to detect and confirm penicillin residues in milk, meat, and other food products.
• Biochemical Reagent: Serves as a specific enzyme in biochemical studies and enzymatic reaction systems.
• Microbiological Media Preparation: Added to culture media to neutralize penicillin, allowing for the growth of penicillin-sensitive organisms.

Basic Information

Product Name	Penicillinase
CAS No.	9001-74-5
Molecular Formula	N/A (Enzyme)
Molecular Weight	~29 kDa (Approximate)
Synonyms	β-lactamase; Penicillin β-lactamase; Penicillin amidase; Neutrapen; Benzylpenicillinase; Penicillinase from Bacillus cereus; EC 3.5.2.6
EINECS	232-645-1

Quality Control

Our Penicillinase is produced and tested under strict quality management systems. Each batch is characterized for specific activity, purity, and stability to ensure consistent performance. A comprehensive Certificate of Analysis (COA) detailing assay, protein content, and microbiological specifications is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term stability, avoid repeated freeze-thaw cycles and store desiccated.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (IR)	Conforms
Specific Activity	≥ 1,500 units/mg protein
Protein Content (Biuret)	Contact for details
pH (in solution)	6.0 - 7.5
Loss on Drying	≤ 5.0 %
Microbial Limits	Meets Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.