Description

Coagulation Factor VII, Human is a highly purified, single-chain glycoprotein that plays a critical role in the initiation of the blood coagulation cascade. This product is essential for research, diagnostic, and therapeutic applications where precise control of hemostasis is required. It is primarily utilized by biotechnology firms, pharmaceutical manufacturers, and clinical research laboratories developing treatments for bleeding disorders such as hemophilia A or B with inhibitors.

Application

• Therapeutic Agent Production: Key active pharmaceutical ingredient (API) in the manufacture of recombinant or plasma-derived Factor VIIa concentrates for treating congenital or acquired bleeding disorders.
• Biomedical Research: Used as a critical reagent in studies of the extrinsic pathway of blood coagulation, thrombosis models, and hemostasis mechanisms.
• Diagnostic Kit Manufacturing: Serves as a reference standard or key component in clotting assays, such as prothrombin time (PT) tests, to assess coagulation factor deficiencies.
• Cell Culture & Biochemistry: Employed in specialized cell culture systems and enzymatic studies requiring the specific activation of Factor X.
• Quality Control & Standardization: Used by regulatory and quality control laboratories to calibrate equipment and validate assays for coagulation factor products.

Basic Information

Product Name	Coagulation Factor VII, Human
CAS No.	9001-25-6
Molecular Formula	Contact for details
Molecular Weight	~50 kDa (Single-chain form)
Synonyms	Factor VII; Proconvertin; Stable Factor; Blood Coagulation Factor VII; Serum Prothrombin Conversion Accelerator (SPCA); Coagulation Factor VIIa (activated form); FVII; F7; Eptacog Alfa (activated, recombinant); NovoSeven® (brand name)
EINECS	Contact for details

Quality Control

Our Coagulation Factor VII, Human is manufactured and tested under strict quality systems. Each batch is characterized for identity, purity, potency, and safety, adhering to relevant guidelines for biological substances. A comprehensive Certificate of Analysis (COA) detailing specifications such as specific activity, purity by SDS-PAGE, and absence of relevant impurities is provided with every shipment to ensure traceability and compliance for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under controlled humidity conditions after use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (SDS-PAGE / Activity)	Conforms
Purity (SDS-PAGE)	≥ 95% (Single chain)
Specific Activity	Contact for details
Protein Content (UV)	Contact for details
pH (in solution)	6.5 - 7.5
Endotoxin (LAL)	< 1.0 EU/mg
Sterility (Membrane Filtration)	Sterile
Moisture Content (KF)	< 3.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.