Description

n-Demethyl Erythromycin A is a key semi-synthetic derivative of the macrolide antibiotic erythromycin, specifically modified at the amino sugar moiety. This structural alteration is crucial for the development of advanced antibiotic agents and for research into overcoming bacterial resistance mechanisms. It serves as a vital pharmaceutical intermediate for researchers and manufacturers in the antibiotic synthesis and medicinal chemistry sectors.

Application

• Pharmaceutical Intermediate: Primary building block for synthesizing next-generation macrolide antibiotics, including clarithromycin and other derivatives with improved pharmacokinetic profiles.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to understand the impact of N-methylation on antibacterial activity and bacterial ribosome binding.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for the identification and quantification of erythromycin-related compounds.
• Biochemical Research: Employed in studies investigating the biosynthesis and enzymatic modification of macrolide antibiotics.
• Process Development: Utilized in the development and optimization of chemical and enzymatic synthesis routes for complex antibiotic molecules.

Basic Information

Item	Details
Product Name	n-Demethyl Erythromycin A
CAS No.	992-62-1
Molecular Formula	C36H65NO12
Molecular Weight	703.90 g/mol
Synonyms	Erythromycin B; 3''-N-Demethylerythromycin A; (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione; Demethylerythromycin; N-Demethylerythromycin
EINECS	Contact for details

Quality Control

Our n-Demethyl Erythromycin A is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.