Description

Chlorpromazine Sulfoxide is a key pharmaceutical intermediate and metabolite of the antipsychotic drug chlorpromazine. This compound is critical for research and development in neuropharmacology, serving as a reference standard for analytical studies and metabolic pathway investigations. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and academic research institutions engaged in drug metabolism, pharmacokinetics, and quality control of phenothiazine-derived therapeutics.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of chlorpromazine and its metabolites in drug substance and finished product analysis.
• Metabolite Research: Essential for in vitro and in vivo studies investigating the metabolic pathways, pharmacokinetics, and bioavailability of chlorpromazine.
• Analytical Method Development: Serves as a critical component in developing and validating High-Performance Liquid Chromatography (HPLC), Liquid Chromatography-Mass Spectrometry (LC-MS), and other analytical methods.
• Impurity Profiling: Employed to identify and control sulfoxide-related impurities during the manufacturing and stability testing of chlorpromazine Active Pharmaceutical Ingredients (APIs).
• Pharmacological Studies: Used in research to understand the activity, toxicity, and degradation profiles of phenothiazine derivatives.
• Quality Control Laboratories: A vital tool for ensuring batch-to-batch consistency and compliance with pharmacopoeial standards (e.g., USP, EP) in pharmaceutical quality assurance.

Basic Information

Product Name	Chlorpromazine Sulfoxide
CAS No.	969-99-3
Molecular Formula	C17H19ClN2OS
Molecular Weight	334.86 g/mol
Synonyms	2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine 5-Oxide; Chlorpromazine S-Oxide; CPZ Sulfoxide; 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine S-Oxide; Levomepromazine Sulfoxide (related isomer); Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, 5-oxide
EINECS	Contact for details

Quality Control

Our Chlorpromazine Sulfoxide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the rigorous standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.