Description

Methyllithium is a highly reactive organolithium compound, widely recognized as a powerful methylating agent and strong base in synthetic chemistry. Its exceptional nucleophilicity and basicity make it indispensable for creating carbon-carbon bonds and deprotonating weak acids. This reagent is critical for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, enabling the synthesis of complex molecules and novel polymers. We supply high-purity Methyllithium CAS NO 917-54-4 to support innovation and scale-up in these demanding fields.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for methyl group introduction and metallation reactions in active pharmaceutical ingredient (API) development.
• Agrochemical Manufacturing: Used in the synthesis of herbicides, fungicides, and plant growth regulators requiring precise methylation steps.
• Polymer & Material Science: Serves as an initiator or catalyst in anionic polymerization for producing specialized elastomers and block copolymers.
• Fine Chemical Production: Employed in the preparation of specialty chemicals, flavors, and fragrances where selective methylation is required.
• Lithiation Reactions: Effective base for generating lithium enolates and other organometallic intermediates from carbonyl compounds.
• Research & Development: Fundamental tool in academic and industrial R&D labs for exploring new synthetic methodologies and reaction pathways.

Basic Information

Product Name	Methyllithium
CAS No.	917-54-4
Molecular Formula	CH3Li
Molecular Weight	21.98 g/mol
Synonyms	Lithium methanide; Methyl lithium; Methyllithium solution; Lithium methyl; Methyl-lithium; MeLi; Lithium methide
EINECS	213-027-4

Quality Control

Our Methyllithium is manufactured and handled under stringent quality systems to ensure batch-to-batch consistency and reliability. Each lot undergoes comprehensive analysis, including titration for precise assay determination and testing for critical impurities. A Certificate of Analysis (COA) detailing purity, concentration (typically in common solvents like diethyl ether or tetrahydrofuran), and other relevant parameters is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile, pyrophoric, and moisture-sensitive nature, Methyllithium must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, well-ventilated area, away from heat, ignition sources, and oxidizing agents. For solutions, specific storage temperature recommendations depend on the solvent system and concentration; refer to the Safety Data Sheet for detailed handling and storage instructions.

Specification

Item	Specification
Appearance (Solution)	Colorless to slightly yellow clear liquid
Assay (by Titration)	1.0 - 2.0 M in specified solvent (e.g., diethyl ether)
Purity (CH3Li basis)	≥ 95%
Identification (IR/NMR)	Conforms to structure
Water Content (Karl Fischer)	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.