Description

5-(4-Bromophenyl)-5-Oxovaleronitrile is a versatile and high-purity organic building block featuring both a bromophenyl group and a nitrile functionality. This compound is critical for facilitating advanced synthetic transformations in pharmaceutical and agrochemical research and development. It serves as a key intermediate for medicinal chemists and process development scientists working on active pharmaceutical ingredients (APIs), fine chemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex drug molecules, particularly those requiring bromoaryl or nitrile functional groups for further derivatization.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides where its specific structure imparts desired biological activity.
• Material Science Research: Serves as a precursor in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromophenyl moiety makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings to create complex biaryl structures.
• Nitrile Transformation Chemistry: The nitrile group can be hydrolyzed to carboxylic acids, reduced to amines, or used in heterocycle formation (e.g., tetrazoles).
• Chemical Biology & Proteomics: Employed as a scaffold or linker in the design of chemical probes and enzyme inhibitors for target identification and validation.

Basic Information

Product Name	5-(4-Bromophenyl)-5-Oxovaleronitrile
CAS No.	898766-86-4
Molecular Formula	C11H10BrNO
Molecular Weight	252.11 g/mol
Synonyms	4-Bromobenzoylbutyronitrile; 5-(4-Bromobenzoyl)valeronitrile; 4'-Bromo-γ-oxobenzenebutanenitrile; 4-Bromophenyl 4-cyanobutyl ketone; γ-Oxo-4'-bromobenzenebutanenitrile; 5-(4-Bromophenyl)-5-oxopentanenitrile; 4-Bromobenzoyl propyl cyanide; 898766-86-4
EINECS	Contact for details

Quality Control

Our 5-(4-Bromophenyl)-5-Oxovaleronitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.