Description

4-(3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Morpholine is a high-value, synthetically versatile boronic ester derivative, primarily used as a key building block in modern organic synthesis. Its core value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing biaryl or heterobiaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air-tolerant boronate reagent for palladium-catalyzed coupling with aryl/heteroaryl halides or triflates.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require fluorinated aromatic structures.
• Material Science: Building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Intermediate for synthesizing complex ligands containing morpholine and fluorophenyl groups for catalysis.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Used in the modular synthesis of bifunctional molecules for targeted protein degradation.

Basic Information

Item	Details
Product Name	4-(3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Morpholine
CAS No.	897016-97-6
Molecular Formula	C17H25BFNO3
Molecular Weight	321.20 g/mol
Synonyms	4-[(3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl]morpholine; 2-(4-((Morpholin-4-yl)methyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)benzyl)morpholine; 3-Fluoro-4-(morpholinomethyl)phenylboronic acid pinacol ester; (3-Fluoro-4-(morpholinomethyl)phenyl)boronic acid pinacol ester; CAS 897016-97-6
EINECS	Contact for details

Quality Control

Our production of 4-(3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Morpholine adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, critical for sensitive cross-coupling applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, NMR, and MS. We support cGMP and ISO 9001 compliant manufacturing for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maximize long-term stability, as boronic esters can be sensitive to prolonged exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.