Description

Amg-386,Trebananib CAS NO 894356-79-7 is a potent and selective peptide-Fab fusion protein inhibitor targeting the angiopoietin-1 and -2 (Ang1/Ang2) pathways. This compound is of significant interest for its role in disrupting tumor angiogenesis, a critical process for cancer growth and metastasis. It is primarily utilized by pharmaceutical research and development teams, contract research organizations (CROs), and academic institutions focused on oncology therapeutics and preclinical studies.

Application

• Oncology Research: Key reagent for studying the inhibition of angiogenesis in various cancer models, including ovarian, renal, and other solid tumors.
• Preclinical Drug Development: Used in efficacy and mechanism-of-action studies for novel anti-angiogenic therapeutic candidates.
• Biopharmaceutical Manufacturing: Serves as a critical reference standard or intermediate in the production and quality control of related biologic drugs.
• Academic & Biomedical Research: Employed in cell biology and pathology labs to investigate the Ang/Tie2 signaling pathway and its role in disease.
• Assay Development: Utilized as a standard or control in developing biochemical and cell-based assays for high-throughput screening.

Basic Information

Item	Detail
Product Name	Amg-386,Trebananib
CAS No.	894356-79-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Trebananib; AMG 386; AMG-386; Angiopoietin 1/2-neutralizing peptibody; Anti-ANG1/Ang2 Peptibody
EINECS	Contact for details

Quality Control

Our Amg-386,Trebananib is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including purity assessment and identity confirmation. A Certificate of Analysis (COA) documenting specific test results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Biological Activity	Assessed by cell-based assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.