Description

n-(tert-Butoxycarbonyl)-n-Methylmethanesulfonamide is a specialized sulfonamide derivative featuring a tert-butoxycarbonyl (Boc) protecting group. This compound is a critical building block in modern organic synthesis, particularly for the controlled introduction of the methylsulfonamide moiety. It is primarily utilized by pharmaceutical and fine chemical research & development teams engaged in the synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials. Its role is essential for creating complex molecular architectures with high precision and yield.

Application

• Pharmaceutical Intermediate: A key reagent in the multi-step synthesis of potential drug candidates, especially those requiring sulfonamide functional groups.
• Peptide Mimetics & PROTACs: Used in the construction of peptide-like molecules and Proteolysis-Targeting Chimeras (PROTACs) for targeted protein degradation.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides, fungicides, and insecticides with sulfonamide activity.
• Material Science Research: Employed in the synthesis of monomers or additives for specialized polymers and advanced functional materials.
• Chemical Biology Probes: Useful for labeling or modifying biomolecules to study biological pathways and interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	n-(tert-Butoxycarbonyl)-n-Methylmethanesulfonamide
CAS No.	894351-83-8
Molecular Formula	C8H17NO4S
Molecular Weight	223.29 g/mol
Synonyms	Boc-N-methyl-methanesulfonamide; N-(tert-Butoxycarbonyl)-N-methylmethanesulfonamide; N-Boc-N-methylmethanesulfonamide; tert-Butyl N-(methylsulfonyl)-N-methylcarbamate; N-Methyl-N-[(2-methyl-2-propanyl)oxy]carbonyl]methanesulfonamide; Methylsulfonamide, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-; Boc-N(Me)-Ms
EINECS	Contact for details

Quality Control

Our n-(tert-Butoxycarbonyl)-n-Methylmethanesulfonamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications in cGMP (Current Good Manufacturing Practice) environments for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.