Description

5-[Bis(tert-Butyl)Phosphino]-1-(1-Naphthalenyl)-1H-Pyrazole is a specialized organophosphorus ligand with a sterically hindered, electron-rich phosphine center. This compound matters as a critical catalyst component in cross-coupling reactions, enabling the efficient synthesis of complex organic molecules. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for developing new active ingredients and high-performance polymers.

Application

• Catalyst Ligand in Cross-Coupling Reactions: A key component in Buchwald-Hartwig amination, Suzuki-Miyaura, and Negishi couplings for C–N and C–C bond formation.
• Pharmaceutical Intermediate Synthesis: Enables the production of complex, nitrogen-containing heterocycles found in active pharmaceutical ingredients (APIs).
• Agrochemical Research & Development: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring selective coupling steps.
• Material Science & Polymer Chemistry: Facilitates the creation of conjugated polymers and organic electronic materials via metal-catalyzed polycondensation.
• Asymmetric Catalysis: Serves as a precursor or auxiliary ligand for developing chiral catalysts in stereoselective synthesis.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new catalytic transformations in laboratory settings.

Basic Information

Product Name	5-[Bis(tert-Butyl)Phosphino]-1-(1-Naphthalenyl)-1H-Pyrazole
CAS No.	894085-97-3
Molecular Formula	C21H27N2P
Molecular Weight	338.43 g/mol
Synonyms	1-(Naphthalen-1-yl)-5-[bis(tert-butyl)phosphanyl]-1H-pyrazole; 5-[Di-tert-butylphosphino]-1-(1-naphthyl)pyrazole; 1-(1-Naphthyl)-5-(di-tert-butylphosphino)pyrazole; DTBNpP; t-Bu-PNP; (1-Naphthyl)-di-tert-butylphosphino-pyrazole; Di-tert-butyl(1-(naphthalen-1-yl)-1H-pyrazol-5-yl)phosphine
EINECS	Contact for details

Quality Control

Every batch of 5-[Bis(tert-Butyl)Phosphino]-1-(1-Naphthalenyl)-1H-Pyrazole undergoes rigorous analytical testing to ensure high purity and consistency for catalytic applications. Our quality commitment includes verification against in-house reference standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, the container should only be opened in an inert glovebox or under a positive pressure of inert gas.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.