Description

2-Chloro-4-(Trifluoromethoxy)Bromobenzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the unique properties of the trifluoromethoxy and halogen substituents.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and other synthetic methodologies.
• Material Science Research: Employed in the synthesis of organic electronic materials, liquid crystals, and polymers where specific halogenated aromatic units are required.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct biaryl systems.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific halogenated scaffold.

Basic Information

Product Name	2-Chloro-4-(Trifluoromethoxy)Bromobenzene
CAS No.	892845-59-9
Molecular Formula	C7H3BrClF3O
Molecular Weight	275.45 g/mol
Synonyms	1-Bromo-2-chloro-4-(trifluoromethoxy)benzene; Benzene, 1-bromo-2-chloro-4-(trifluoromethoxy)-; 2-Chloro-4-(trifluoromethoxy)-1-bromobenzene; 2-Chloro-1-bromo-4-(trifluoromethoxy)benzene; 4-Bromo-3-chlorophenyl trifluoromethyl ether; 3-Chloro-4-bromophenyl trifluoromethyl ether
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(Trifluoromethoxy)Bromobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.