Description

Atenolol β-D-Glucuronide is a crucial reference standard and metabolite of the widely used β-blocker, atenolol. This high-purity compound is essential for analytical research, method development, and quality control in pharmaceutical and bioanalytical laboratories. It is primarily utilized by researchers and quality assurance professionals in the pharmaceutical, contract research organization (CRO), and clinical diagnostics sectors for precise quantification and metabolic studies.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the quantitative analysis of atenolol and its metabolites in drug substances and finished products.
• Bioanalytical Research: Critical for developing and validating LC-MS/MS, HPLC, and other analytical methods to study atenolol pharmacokinetics, metabolism, and bioequivalence.
• Metabolite Identification & Profiling: Serves as a definitive standard to identify and quantify the glucuronidated metabolite in in vitro and in vivo metabolism studies.
• Doping Control & Forensic Analysis: Employed in sports anti-doping and forensic toxicology laboratories as a calibration standard for detecting atenolol misuse.
• Clinical Diagnostics: Used in the calibration of assays designed to monitor atenolol levels in patient plasma or serum for therapeutic drug monitoring (TDM).
• Impurity Standard: Acts as a specified impurity standard in the quality control of atenolol active pharmaceutical ingredient (API) to ensure product safety and compliance with ICH guidelines.

Basic Information

Product Name	Atenolol β-D-Glucuronide
CAS No.	889359-84-6
Molecular Formula	C22H30N2O9
Molecular Weight	466.48 g/mol
Synonyms	Atenolol Glucuronide; Atenolol β-D-Glucopyranosiduronic Acid; 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide β-D-Glucopyranosiduronic Acid; Atenolol O-β-D-Glucuronide; Atenolol Metabolite (Glucuronide); 1-{4-[2-Hydroxy-3-(isopropylamino)propoxy]phenyl}acetamide β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Atenolol β-D-Glucuronide is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for use as a reference standard. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While not officially certified, our material is characterized and qualified against industry standards for pharmaceutical impurities and metabolite research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.