Description

n-Fmoc-(S)-2-Hexylglycine is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected α-amino group and a hexyl side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of lipophilic, branched-chain modifications into peptide sequences. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and bioactive compounds where enhanced membrane permeability and metabolic stability are desired.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides with hydrophobic character.
• Pharmaceutical Research: For constructing peptide-based drug candidates, hormone analogs, and diagnostic agents that require specific side-chain functionalities.
• Peptidomimetic Design: Incorporation into scaffolds to mimic protein structures and create molecules with improved oral bioavailability and proteolytic resistance.
• Bioconjugation & Labeling: Serves as a versatile intermediate for attaching peptides to surfaces, carriers, or reporter molecules via its carboxylic acid group.
• Chemical Biology Probes: Used in the synthesis of tool compounds for studying protein-protein interactions and enzyme mechanisms.
• Material Science: Potential use in creating functionalized biomaterials and self-assembling peptide nanostructures.

Basic Information

Product Name	n-Fmoc-(S)-2-Hexylglycine
CAS No.	888725-91-5
Molecular Formula	C23H27NO4
Molecular Weight	381.47 g/mol
Synonyms	Fmoc-(S)-2-Hexylglycine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-hexylacetic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-2-hexylglycine; Fmoc-S-2-Hexyl-Gly-OH; N-α-Fmoc-S-2-hexylglycine; (2S)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)amino]-2-hexylacetic acid; Fmoc-2-Hexylglycine-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-(S)-2-Hexylglycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.