Description

1-Bromo-3-(2,2,2-trifluoroethoxy)benzene is a high-value fluorinated aromatic building block, essential for introducing both bromo and trifluoroethoxy functional groups into complex molecular architectures. This compound is critical for researchers and manufacturers requiring precise structural modifications to enhance the biological activity, metabolic stability, or physical properties of target molecules. It is primarily sought after by the pharmaceutical, agrochemical, and advanced materials industries for applications in drug discovery, crop protection, and specialty polymer synthesis.

Application

• Pharmaceutical Intermediate: Key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the trifluoroethoxy group can improve lipophilicity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), contributing to improved performance and durability.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl and conjugated systems.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating specialized compound libraries.
• Fluorinated Polymer Modifier: Can be incorporated into polymer backbones to impart unique properties such as chemical resistance, low surface energy, and thermal stability.

Basic Information

Product Name	1-Bromo-3-(2,2,2-Trifluoroethoxy)Benzene
CAS No.	888327-41-1
Molecular Formula	C8H6BrF3O
Molecular Weight	255.03 g/mol
Synonyms	3-Bromo-1-(2,2,2-trifluoroethoxy)benzene; m-Bromo(2,2,2-trifluoroethoxy)benzene; 1-Bromo-3-(2,2,2-trifluoroethoxy)benzene; Benzene, 1-bromo-3-(2,2,2-trifluoroethoxy)-; 3-(2,2,2-Trifluoroethoxy)bromobenzene; 3-Bromophenyl 2,2,2-trifluoroethyl ether
EINECS	Contact for details

Quality Control

Our production of 1-Bromo-3-(2,2,2-trifluoroethoxy)benzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, NMR, and MS to confirm identity and quantify impurities. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality documentation to meet specific customer and regulatory requirements (e.g., ICH guidelines, USP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.