Description

4-Bromo-1-Difluoromethoxy-2-Methyl-Benzene is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoromethoxy and bromo substituents on a benzene ring. This compound is critical for medicinal chemists as it serves as a versatile building block for introducing specific functional groups into target molecules, enabling the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized in the research and synthesis of new drug candidates, particularly in therapeutic areas where fluorinated compounds are valued for their metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral drugs.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the difluoromethoxy group can enhance biological activity and environmental stability.
• Material Science: Serves as a monomer or precursor in the synthesis of specialty polymers and liquid crystals, contributing to materials with specific optical or electronic properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex biaryl structures common in many modern pharmaceuticals.
• Fluorine Chemistry Studies: Acts as a valuable substrate for investigating the effects of fluorine and difluoromethoxy groups on molecular conformation and reactivity in research laboratories.

Basic Information

Product Name	4-Bromo-1-Difluoromethoxy-2-Methyl-Benzene
CAS No.	888327-32-0
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	1-Bromo-4-(difluoromethoxy)-2-methylbenzene; 2-Methyl-4-bromophenyl difluoromethyl ether; 4-Bromo-2-methylanisole, difluoro; 4-Bromo-α,α-difluoro-2-methylanisole; 2-Methyl-4-bromo-α,α-difluoroanisole; Benzene, 4-bromo-1-(difluoromethoxy)-2-methyl-; (4-Bromo-2-methylphenyl)difluoromethyl ether
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-1-Difluoromethoxy-2-Methyl-Benzene is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency, supported by comprehensive analytical documentation. Our standard quality control includes assays by GC/HPLC, identity confirmation via FT-IR and NMR, and stringent limits for related substances and residual solvents. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to ensure full traceability and compliance with your R&D or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.