Description

n-Boc-Cyclopropyl-Dl-Alanine is a protected amino acid derivative featuring a cyclopropyl side chain and a tert-butoxycarbonyl (Boc) protecting group on the amine. This compound is a crucial chiral building block in the synthesis of complex molecules, offering a versatile scaffold for introducing constrained conformational elements. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology industries for the development of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly those targeting metabolic and central nervous system disorders.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate the conformationally restricted cyclopropyl-alanine residue into peptide chains, modifying their biological activity and stability.
• Protease Inhibitor Development: Serves as a core structure for designing inhibitors of various proteases, where the cyclopropyl group mimics transition states or binds in specific enzyme pockets.
• Chemical Biology Research: Employed in the synthesis of activity-based probes and labeled compounds for studying enzyme function and protein-protein interactions.
• Agrochemical Research: Utilized as an intermediate in the discovery of novel herbicides and pesticides with unique modes of action.
• Material Science: Potential building block for specialty polymers and advanced materials requiring specific stereochemical and functional properties.

Basic Information

Product Name	n-Boc-Cyclopropyl-Dl-Alanine
CAS No.	888323-62-4
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	(±)-1-(tert-Butoxycarbonylamino)cyclopropanecarboxylic Acid; DL-1-[(tert-Butoxycarbonyl)amino]cyclopropanecarboxylic Acid; N-Boc-1-Aminocyclopropanecarboxylic Acid (DL); N-(tert-Butoxycarbonyl)-1-aminocyclopropanecarboxylic Acid; Boc-Cpr-OH (DL); 1-Boc-amino-1-cyclopropanecarboxylic Acid; N-Boc-1-amino-1-cyclopropanecarboxylic Acid, Racemic; tert-Butyl (1-carboxycyclopropyl)carbamate
EINECS	Contact for details

Quality Control

Our n-Boc-Cyclopropyl-Dl-Alanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Racemic mixture (DL)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.