Description

1-Bromo-3,4-difluoro-2-methoxybenzene is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique substitution pattern, which allows for selective functionalization and the introduction of complexity into target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly those containing difluoromethoxy or related pharmacophores.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the fluorine atoms enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for liquid crystals, organic semiconductors, and specialty polymers requiring specific electronic properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Organic Synthesis Research: Employed in academic and industrial R&D for method development and the construction of complex, fluorinated aromatic systems.

Basic Information

Product Name	1-Bromo-3,4-difluoro-2-methoxybenzene
CAS No.	888318-22-7
Molecular Formula	C7H5BrF2O
Molecular Weight	223.02 g/mol
Synonyms	2-Bromo-4,5-difluoroanisole; 4,5-Difluoro-2-bromoanisole; 3,4-Difluoro-2-methoxybromobenzene; 1-Bromo-3,4-difluoro-2-methoxy-benzene; Benzene, 1-bromo-3,4-difluoro-2-methoxy-; Anisole, 2-bromo-4,5-difluoro-
EINECS	Contact for details

Quality Control

Our 1-Bromo-3,4-difluoro-2-methoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.