Description

Propargyl-Peg4-Ch2Co2Tbu is a specialized bifunctional PEG linker featuring a propargyl group and a protected carboxylic acid. This compound is a critical building block in bioconjugation and click chemistry, enabling the precise and efficient modification of biomolecules, polymers, and surfaces. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require high-purity, functional linkers for drug delivery systems, diagnostic assays, and polymer synthesis.

Application

• Bioconjugation and Click Chemistry: Serves as a key reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to attach labels, drugs, or probes to peptides, proteins, and antibodies.
• ADC (Antibody-Drug Conjugate) Development: Used to construct stable, cleavable linkers for connecting cytotoxic payloads to monoclonal antibodies.
• Polymer and Dendrimer Synthesis: Acts as a functional monomer or cross-linker to introduce alkyne handles into PEG-based polymers, hydrogels, and dendritic structures.
• Surface Functionalization: Enables the modification of nanoparticles, chips, and other solid supports with alkyne groups for subsequent biomolecule immobilization.
• Proteomics and Diagnostics: Facilitates the labeling and purification of biomolecules in activity-based protein profiling (ABPP) and diagnostic assay development.
• Materials Science: Incorporated into smart materials and coatings to impart specific chemical reactivity or biocompatibility.

Basic Information

Item	Detail
Product Name	Propargyl-Peg4-Ch2Co2Tbu
CAS No.	888010-02-4
Molecular Formula	C20H36O8
Molecular Weight	404.5 g/mol
Synonyms	Propargyl-PEG4-acid, t-butyl ester; 2,5,8,11-Tetraoxatetradec-13-ynoic acid, 14-(1,1-dimethylethyl) ester; Propargyl-PEG4-CH2COOtBu; 1-Propargyl-3,6,9,12-tetraoxapentadecan-15-oic acid tert-butyl ester; Tert-butyl 2,5,8,11-tetraoxa-14-hexadecynoate; Alkyne-PEG4-t-butyl ester; Propargyl tetraethylene glycol carboxylic acid t-butyl ester; Propargyl-O1-(2-(2-(2-(2-(t-butoxy)-2-oxoethoxy)ethoxy)ethoxy)ethyl)
EINECS	Contact for details

Quality Control

Every batch of Propargyl-Peg4-Ch2Co2Tbu is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure high purity and batch-to-batch consistency. Our standard quality commitment includes verification by NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) in a desiccator to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.