Description

4-Difluoromethoxyphenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron reagent. This compound is a protected boronic acid derivative, offering enhanced stability and handling characteristics compared to its free acid form, which is critical for complex synthetic workflows. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing biaryl and heterobiaryl scaffolds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing difluoromethoxy-substituted aromatic systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the difluoromethoxyphenyl moiety imparts desirable biological activity.
• Material Science Research: Employed in the creation of advanced organic materials, such as ligands for catalysts, organic semiconductors, and liquid crystals.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air-tolerant coupling partner with various aryl/heteroaryl halides or triflates to form new carbon-carbon bonds.
• Chemical Library Development: A valuable reagent for medicinal chemistry and high-throughput screening libraries to explore new chemical space.

Basic Information

Product Name	4-Difluoromethoxyphenylboronic Acid Pinacol Ester
CAS No.	887757-48-4
Molecular Formula	C14H18BF2O3
Molecular Weight	283.10 g/mol
Synonyms	4-(Difluoromethoxy)phenylboronic Acid Pinacol Ester; [4-(Difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-[4-(Difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(Difluoromethoxy)benzeneboronic Acid Pinacol Ester; Pinacol 4-(Difluoromethoxy)phenylboronate
EINECS	Contact for details

Quality Control

Every batch of 4-Difluoromethoxyphenylboronic Acid Pinacol Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and development. A Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC/NMR), identity, and impurity profile is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. This material is hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to maintain stability and purity. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.