Description

tert-Butyl 2-cyanoazetidine-1-carboxylate is a high-value, protected azetidine building block essential for modern pharmaceutical and agrochemical research. Its core value lies in providing a versatile, nitrogen-containing heterocyclic scaffold that is readily functionalized for the synthesis of complex bioactive molecules. This compound is critically needed by medicinal chemists and process development scientists in the pharmaceutical industry for constructing novel drug candidates, particularly in the development of protease inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of azetidine-based active pharmaceutical ingredients (APIs) and preclinical candidates.
• Medicinal Chemistry: Serves as a versatile scaffold in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its protected amine and nitrile functionality.
• Protease Inhibitor Synthesis: Used in the research and development of novel inhibitors targeting various proteases.
• Agrochemical Research: Employed as a building block for novel herbicides, fungicides, and insecticides that incorporate the azetidine ring.
• Chemical Biology: Utilized in the synthesis of molecular probes and tool compounds for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific chiral or functionalized azetidine derivatives.

Basic Information

Product Name	tert-Butyl 2-Cyanoazetidine-1-Carboxylate
CAS No.	887588-82-1
Molecular Formula	C9H14N2O2
Molecular Weight	182.22 g/mol
Synonyms	1-Boc-2-cyanoazetidine; 2-Cyanoazetidine-1-carboxylic acid tert-butyl ester; tert-Butyl 2-cyano-1-azetidinecarboxylate; 1-(tert-Butoxycarbonyl)-2-cyanoazetidine; Azetidine-1-carboxylic acid, 2-cyano-, 1,1-dimethylethyl ester; Boc-2-cyanoazetidine; 2-Cyano-1-azetidinecarboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-cyanoazetidine-1-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.