Description

n-Succinimidyloxycarbonylpentadecyl Methanethiosulfonate is a specialized heterobifunctional crosslinking reagent featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and a thiol-reactive methanethiosulfonate (MTS) group. This compound is engineered for the controlled and site-specific conjugation of biomolecules, enabling the formation of stable amide bonds with primary amines and disulfide bonds with thiols. It is a critical tool for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, protein labeling, and surface functionalization.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a cleavable linker for attaching cytotoxic payloads to monoclonal antibodies via amine and thiol groups.
• Protein and Peptide Modification: Enables site-specific labeling of proteins with fluorophores, biotin, or other probes for imaging and detection assays.
• Surface Immobilization Chemistry: Used to functionalize gold surfaces, nanoparticles, or biosensor chips with biomolecules for diagnostic and research applications.
• Polymer Conjugation: Facilitates the attachment of peptides or proteins to polymeric carriers for drug delivery systems.
• Stable Disulfide Bridge Formation: Creates reversible, redox-sensitive crosslinks within or between proteins for structural studies.
• Biomaterial Engineering: Modifies hydrogels or other biomaterials to incorporate bioactive ligands for cell culture and tissue engineering.

Basic Information

Product Name	n-Succinimidyloxycarbonylpentadecyl Methanethiosulfonate
CAS No.	887407-52-5
Molecular Formula	C22H39NO6S2
Molecular Weight	477.67 g/mol
Synonyms	15-((2,5-Dioxopyrrolidin-1-yl)oxy)-15-oxopentadecyl methanesulfonothioate; Pentadecyl NHS-MTS; NHS-PEG15-MTS; Heterobifunctional Crosslinker (NHS-MTS); Methanethiosulfonate-PEG15-NHS ester; Succinimidyl pentadecyl methanethiosulfonate; SPDP long-chain analog; Amine-to-Thiol Crosslinker
EINECS	Contact for details

Quality Control

Our n-Succinimidyloxycarbonylpentadecyl Methanethiosulfonate is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, critical for sensitive bioconjugation workflows. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional integrity. We support cGMP and ISO 9001 compliant manufacturing for research and pre-clinical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.