Description

4-(Maleimidomethyl)Cyclohexane-1-Carbonyl-1-(tert-Butyl)Carbazate is a specialized heterobifunctional crosslinking agent designed for advanced bioconjugation and polymer chemistry. This compound is critical for creating stable, site-specific linkages between biomolecules or synthetic polymers, offering superior control over the assembly of complex molecular architectures. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostics, and advanced materials sectors for applications such as antibody-drug conjugate (ADC) development, hydrogel formation, and surface functionalization.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key intermediate for constructing stable, cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Modification: Enables site-specific labeling or immobilization of proteins via the maleimide group's reactivity with thiols.
• Polymer Functionalization: Used to introduce reactive handles into polymer backbones for creating smart materials, hydrogels, and drug delivery systems.
• Surface Chemistry: Facilitates the covalent attachment of biomolecules or other ligands to surfaces for biosensor and microarray development.
• Diagnostic Reagent Synthesis: Serves as a building block for synthesizing reagents used in immunoassays and other diagnostic platforms.
• Materials Science Research: Employed in crosslinking studies and the development of novel polymeric networks with tailored properties.

Basic Information

Product Name	4-(Maleimidomethyl)Cyclohexane-1-Carbonyl-1-(tert-Butyl)Carbazate
CAS No.	887406-71-5
Molecular Formula	C16H23N3O4
Molecular Weight	321.37 g/mol
Synonyms	1-(tert-Butyl) 1'-[4-(Maleimidomethyl)cyclohexanecarbonyl]carbazate; 4-(Maleimidomethyl)-1-[(2-methyl-2-propanyl)oxycarbonyl]hydrazinecarboxylic Acid Cyclohexyl Ester; tert-Butyl (4-(maleimidomethyl)cyclohexanecarbonyl)carbazate; 4-(Maleimidomethyl)cyclohexanecarboxylic Acid tert-Butyl Carbazate; Maleimide-PEG4-t-butyl carbazate (related); Heterobifunctional Crosslinker with Maleimide and tert-Butyl Carbazate; ADC Linker Intermediate; CAS 887406-71-5
EINECS	Contact for details

Quality Control

Our 4-(Maleimidomethyl)Cyclohexane-1-Carbonyl-1-(tert-Butyl)Carbazate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, essential for sensitive bioconjugation applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and cGMP manufacturing needs with appropriate documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.