Description

n-Hydroxysuccinimidyl-2,3-Diphenylquinoxaline-6-Carboxylate is a highly reactive, heterocyclic active ester derivative used as a key labeling and crosslinking reagent in advanced bioconjugation chemistry. Its core value lies in its ability to efficiently and selectively couple with primary amine groups under mild aqueous conditions, forming stable amide bonds. This compound is essential for researchers and manufacturers in the life sciences sector, particularly for developing fluorescent probes, antibody-drug conjugates (ADCs), and other diagnostic and therapeutic biomolecules.

Application

• Fluorescent Probe Synthesis: Acts as a critical linker for attaching fluorophores (e.g., quinoxaline-based dyes) to proteins, antibodies, and peptides for bioimaging and diagnostic assays.
• Antibody-Drug Conjugate (ADC) Development: Serves as a heterobifunctional crosslinker to connect cytotoxic payloads to monoclonal antibodies, enabling targeted cancer therapies.
• Protein and Peptide Labeling: Facilitates the site-specific modification of biomolecules with various tags for studies in proteomics, enzyme kinetics, and receptor-ligand interactions.
• Biomaterial Functionalization: Used to conjugate bioactive molecules to polymer surfaces, nanoparticles, or hydrogels to create advanced scaffolds for tissue engineering and drug delivery systems.
• Diagnostic Kit Manufacturing: Employed in the production of enzyme-linked immunosorbent assay (ELISA) kits and other immunoassays by labeling detection antibodies.
• Small Molecule Derivatization: Enables the introduction of a quinoxaline chromophore or other functionalities into amine-containing compounds for analytical or synthetic purposes.

Basic Information

Product Name	n-Hydroxysuccinimidyl-2,3-Diphenylquinoxaline-6-Carboxylate
CAS No.	887406-55-5
Molecular Formula	C29H19N3O5
Molecular Weight	489.48 g/mol
Synonyms	2,3-Diphenylquinoxaline-6-carboxylic acid N-hydroxysuccinimide ester; 6-(((2,5-Dioxopyrrolidin-1-yl)oxy)carbonyl)-2,3-diphenylquinoxaline; NHS ester of 2,3-diphenylquinoxaline-6-carboxylic acid; Quinoxaline NHS ester; DPAQ-NHS; 2,3-Diphenylquinoxaline-6-Carboxylate, N-Succinimidyl Ester; N-Succinimidyl 2,3-diphenylquinoxaline-6-carboxylate
EINECS	Contact for details

Quality Control

Our n-Hydroxysuccinimidyl-2,3-Diphenylquinoxaline-6-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.