Description

4-(Hydroxymethyl)Benzyl Methanethiosulfonate is a specialized thiol-reactive chemical reagent featuring a hydroxymethylbenzyl spacer. This compound matters for its role as a key intermediate and cross-linking agent in advanced bioconjugation and protein modification strategies. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for developing targeted drug delivery systems, diagnostic assays, and novel biomaterials.

Application

• Bioconjugation Reagent: For site-specific modification of proteins, peptides, and antibodies via cysteine residues.
• Cross-linking Agent: Used in the development of stable protein-protein or protein-ligand conjugates for therapeutic and diagnostic applications.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs.
• Surface Functionalization: Enables the covalent attachment of biomolecules to nanoparticles, biosensors, and other solid supports.
• Proteomics Research: A tool for studying protein structure, function, and interactions through selective labeling.
• Polymer Chemistry: Used to introduce reactive thiol groups or disulfide linkages into polymer backbones for smart material design.

Basic Information

Product Name	4-(Hydroxymethyl)Benzyl Methanethiosulfonate
CAS No.	887406-47-5
Molecular Formula	C9H12O3S2
Molecular Weight	232.32 g/mol
Synonyms	4-(Hydroxymethyl)benzyl methanesulfonothioate; MBTS-Hydroxymethyl; (4-(Hydroxymethyl)phenyl)methyl methanethiosulfonate; Hydroxymethylbenzyl MTS; p-(Hydroxymethyl)benzyl methanethiosulfonate; Thiol-reactive hydroxymethylbenzyl linker; MTSL-Hydroxymethylbenzyl derivative
EINECS	Contact for details

Quality Control

Our 4-(Hydroxymethyl)Benzyl Methanethiosulfonate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content	≤ 1.0%
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.