Description

2-Trifluoromethyl-5-Nitrobenzonitrile is a high-value, multi-functional aromatic intermediate featuring both a strong electron-withdrawing trifluoromethyl group and a reactive nitrile functionality. This compound is critical for the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its unique structure imparts desirable properties like metabolic stability and lipophilicity. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel compounds and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry for creating molecules with enhanced bioavailability and target specificity.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing advanced electronic materials used in displays and organic light-emitting diodes (OLEDs).
• Dye & Pigment Intermediate: Employed in the production of specialized dyes and pigments, leveraging the nitro and nitrile groups for color development and stability.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) for constructing complex biaryl systems.
• Organic Synthesis & Research: A valuable reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating complex molecular architectures.

Basic Information

Item	Details
Product Name	2-Trifluoromethyl-5-Nitrobenzonitrile
CAS No.	887350-95-0
Molecular Formula	C8H3F3N2O2
Molecular Weight	216.12 g/mol
Synonyms	5-Nitro-2-(trifluoromethyl)benzonitrile; 2-(Trifluoromethyl)-5-nitrobenzonitrile; α,α,α-Trifluoro-5-nitro-o-tolunitrile; 5-Nitro-α,α,α-trifluoro-o-tolunitrile; Benzonitrile, 2-(trifluoromethyl)-5-nitro-; 2-Trifluoromethyl-5-nitro-benzonitrile
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethyl-5-Nitrobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality ensures the material meets the stringent requirements for research and cGMP-grade manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and performance. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.