Description

3,5-Bis(Trifluoromethyl)Phenylglyoxylamide is a high-value, fluorinated organic building block characterized by its reactive glyoxylamide moiety flanked by two strongly electron-withdrawing trifluoromethyl groups. This unique structure makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and agrochemicals, where the introduction of fluorine atoms is key to modulating biological activity, metabolic stability, and lipophilicity. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for the development of new active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly in areas like kinase inhibitors, antiviral agents, and central nervous system (CNS) therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl groups enhance bioactivity and environmental persistence.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for transition metal catalysis, useful in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Acts as a monomer or functionalization agent in the development of fluorinated polymers and advanced organic materials with unique surface properties.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Phenylglyoxylamide
CAS No.	887268-11-3
Molecular Formula	C11H5F6NO2
Molecular Weight	297.16 g/mol
Synonyms	2-Oxo-2-[3,5-bis(trifluoromethyl)phenyl]acetamide; 3,5-Bis(trifluoromethyl)benzoylformamide; α-Keto-3,5-bis(trifluoromethyl)benzeneacetamide; Phenylglyoxylamide, 3,5-bis(trifluoromethyl)-; 3,5-Bis(trifluoromethyl)benzoylcarboxamide; Amide of 3,5-Bis(trifluoromethyl)phenylglyoxylic Acid
EINECS	Contact for details

Quality Control

Every batch of 3,5-Bis(Trifluoromethyl)Phenylglyoxylamide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.