Description

1-Bromo-3-Methyl-5-(Trifluoromethoxy)Benzene, also known as 3-Bromo-5-Methylphenyl Trifluoromethyl Ether or 3-Bromo-5-Methyl-Alpha,Alpha,α-Trifluoroanisole, is a high-value, multi-functional aromatic building block. This compound matters for its unique molecular architecture, combining a bromo substituent for cross-coupling reactions with a trifluoromethoxy group that imparts enhanced metabolic stability and lipophilicity to target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for synthesizing novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group improves biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or building block for specialty polymers, liquid crystals, and organic electronic materials requiring specific fluorine-containing aromatic units.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to create complex biaryl structures.
• Chemical Research & Development: Employed in academic and industrial labs for exploring new synthetic methodologies and creating compound libraries for high-throughput screening.
• Fluorine Chemistry Studies: Acts as a model compound for investigating the electronic and steric effects of the -OCF₃ group in aromatic systems.

Basic Information

Product Name	1-Bromo-3-Methyl-5-(Trifluoromethoxy)Benzene
CAS No.	887266-91-3
Molecular Formula	C₈H₆BrF₃O
Molecular Weight	255.04 g/mol
Synonyms	3-Bromo-5-Methylphenyl Trifluoromethyl Ether; 3-Bromo-5-Methyl-Alpha,Alpha,α-Trifluoroanisole; 1-Bromo-3-Methyl-5-(trifluoromethoxy)benzene; 3-Bromo-5-(trifluoromethoxy)toluene; 5-Bromo-1-methyl-3-(trifluoromethoxy)benzene; m-Bromo-m-methyl-alpha,alpha,α-trifluoroanisole; 3-Methyl-5-(trifluoromethoxy)bromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-Methyl-5-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability, consistency, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed in a dry environment to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.