Description

Vabicaserin Hydrochloride CAS NO 887258-94-8 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) of significant interest in neuropharmacology research and development. Its primary value lies in its role as a key compound for the synthesis and study of novel therapeutic agents targeting specific serotonin receptors. This product is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in the development of central nervous system (CNS) medications.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of advanced investigational drugs and final active pharmaceutical ingredients (APIs).
• Neurological Research: Used in preclinical and clinical research studies focusing on serotonin receptor modulation and related neurological pathways.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Drug Discovery & Development: Integral component in medicinal chemistry programs aimed at discovering new treatments for CNS disorders.
• GMP Manufacturing: Supplied for use in Good Manufacturing Practice (GMP) compliant processes for the production of clinical trial materials.

Basic Information

Product Name	Vabicaserin Hydrochloride
CAS No.	887258-94-8
Molecular Formula	C21H28N2O2 • HCl
Molecular Weight	376.92 g/mol
Synonyms	Vabicaserin HCl; (3aR,4S,7aR)-Hexahydro-4-(phenylmethoxy)-2H-isoindol-2-one hydrochloride; 2H-Isoindol-2-one, hexahydro-4-(phenylmethoxy)-, (3aR,4S,7aR)-, hydrochloride; UNII-5F0W5A6T1H; 5-HT2C receptor agonist (hydrochloride form); SB-649915 (hydrochloride); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Vabicaserin Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR), to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific pharmacopeial standards (e.g., USP, EP) or client requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.