Description

1-Iodo-2-Nitro-4-(Trifluoromethoxy)Benzene is a specialized halogenated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique trifluoromethoxy and nitro substituents, which are key for modulating the electronic properties, lipophilicity, and metabolic stability of target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental persistence.
• Material Science: Serves as a monomer or functionalizing agent in the creation of advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to construct complex biaryl systems.
• Fluorine Chemistry: An important building block for introducing the trifluoromethoxy (OCF3) pharmacophore, a group known to improve a molecule's metabolic stability and membrane permeability.
• Dye and Pigment Synthesis: Utilized in the preparation of specialized nitro- and iodo-substituted dyes and pigments with specific light-absorption properties.

Basic Information

Product Name	1-Iodo-2-Nitro-4-(Trifluoromethoxy)Benzene
CAS No.	886762-35-2
Molecular Formula	C7H3F3INO3
Molecular Weight	348.99 g/mol
Synonyms	2-Nitro-1-iodo-4-(trifluoromethoxy)benzene; 4-(Trifluoromethoxy)-2-nitroiodobenzene; 1-Iodo-2-nitro-4-(trifluoromethoxy)benzene; Benzene, 1-iodo-2-nitro-4-(trifluoromethoxy)-; 886762-35-2
EINECS	Contact for details

Quality Control

Our 1-Iodo-2-Nitro-4-(Trifluoromethoxy)Benzene undergoes rigorous quality testing to ensure compliance with industry standards. Each batch is analyzed to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing purity (typically ≥95% by HPLC), physical characteristics, and spectroscopic data are available upon request. We adhere to strict in-house quality protocols to ensure batch-to-batch consistency for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.