Description

4,5-Difluoro-2-Methoxyphenylacetic Acid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms is critical for modulating biological activity and metabolic stability. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors engaged in the synthesis of novel, high-value compounds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and oncology therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoromethoxy moiety can enhance product efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new fluorination methodologies and constructing complex molecular architectures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale API batches under cGMP conditions.

Basic Information

Product Name	4,5-Difluoro-2-Methoxyphenylacetic Acid
CAS No.	886761-73-5
Molecular Formula	C9H8F2O3
Molecular Weight	202.16 g/mol
Synonyms	2-(4,5-Difluoro-2-methoxyphenyl)acetic Acid; (4,5-Difluoro-2-methoxyphenyl)acetic Acid; 4,5-Difluoro-2-methoxybenzeneacetic Acid; 886761-73-5; 4,5-Difluoro-o-methoxyphenylacetic Acid; α-(4,5-Difluoro-2-methoxyphenyl)acetic Acid
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2-Methoxyphenylacetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical and agrochemical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.