Description

3-Chloro-2,4-Difluorophenylacetic Acid is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of chlorine and fluorine atoms is crucial for modulating biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate a difluorinated phenylacetic acid moiety into complex target molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the halogenated phenylacetic acid structure contributes to efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of fluorinated polymers and advanced organic materials with unique electronic or surface properties.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-Chloro-2,4-Difluorophenylacetic Acid
CAS No.	886761-66-6
Molecular Formula	C8H5ClF2O2
Molecular Weight	206.57 g/mol
Synonyms	2-(3-Chloro-2,4-difluorophenyl)acetic Acid; (3-Chloro-2,4-difluorophenyl)acetic Acid; 3-Chloro-2,4-difluorobenzeneacetic Acid; α-(3-Chloro-2,4-difluorophenyl)acetic Acid; NSC 886761; CAS 886761-66-6
EINECS	Contact for details

Quality Control

Our 3-Chloro-2,4-Difluorophenylacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents. Keep the container tightly sealed when not in use to prevent contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.