Description

2-Chloro-3-(Trifluoromethyl)Anisole is a high-value fluorinated aromatic building block characterized by its chloro and trifluoromethyl substituents on an anisole core. This compound matters for its role as a critical intermediate in the synthesis of advanced agrochemicals and pharmaceuticals, where its unique electronic properties can significantly influence biological activity and metabolic stability. It is primarily needed by R&D chemists and process development teams in the fine chemical, agrochemical, and pharmaceutical industries seeking to introduce these potent functional groups into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and bioactivity.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and charge-transport materials.
• Functional Dye Intermediate: Used in the synthesis of specialized dyes and pigments where halogen and fluorine atoms modify color and stability.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl systems.

Basic Information

Product Name	2-Chloro-3-(Trifluoromethyl)Anisole
CAS No.	886503-84-0
Molecular Formula	C8H6ClF3O
Molecular Weight	210.58 g/mol
Synonyms	1-Chloro-2-methoxy-6-(trifluoromethyl)benzene; 2-Chloro-3-(trifluoromethyl)methoxybenzene; 2-Chloro-α,α,α-trifluoro-3-methoxytoluene; 3-Methoxy-2-chlorobenzotrifluoride; Anisole, 2-chloro-3-(trifluoromethyl)-; 886503-84-0
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-(Trifluoromethyl)Anisole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.