Description

4-Fluoro-2-Methylbenzamide is a high-purity fluorinated aromatic amide building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the fluorine atom and amide group impart critical bioactivity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific structural motifs into novel molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the fluorine substituent enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers and liquid crystals with tailored electronic and optical properties.
• Chemical Biology Probes: Utilized as a scaffold for developing fluorescent tags and molecular probes to study biological processes.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	4-Fluoro-2-Methylbenzamide
CAS No.	886501-45-7
Molecular Formula	C8H8FNO
Molecular Weight	153.15 g/mol
Synonyms	2-Methyl-4-fluorobenzamide; 4-Fluoro-o-toluamide; 4-Fluoro-2-methylbenzoic acid amide; 2-Methyl-4-fluorobenzoic acid amide; 886501-45-7; Benzamide, 4-fluoro-2-methyl-; 4-Fluoro-2-methyl-benzamide; 4-Fluoro-2-methylbenzamide (CAS 886501-45-7)
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Methylbenzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize moisture absorption. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.