Description

2,6-Difluoro-4-Methoxyphenylacetic Acid is a high-value fluorinated aromatic building block of significant importance in advanced organic synthesis. Its core value lies in its unique substitution pattern, which makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where the introduction of fluorine atoms is a key strategy to modulate bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, anti-inflammatory agents, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro-methoxy motif can enhance biological activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic materials, contributing to improved performance in display technologies.
• Advanced Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine into polymer backbones, enhancing chemical resistance, thermal stability, and surface properties.
• Chemical Research & Development: A versatile building block in academic and industrial R&D for exploring new chemical spaces and creating libraries of fluorinated compounds for screening.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules on various scales.

Basic Information

Product Name	2,6-Difluoro-4-Methoxyphenylacetic Acid
CAS No.	886498-98-2
Molecular Formula	C9H8F2O3
Molecular Weight	202.16 g/mol
Synonyms	2-(2,6-Difluoro-4-methoxyphenyl)acetic Acid; (2,6-Difluoro-4-methoxyphenyl)acetic Acid; 2,6-Difluoro-4-methoxybenzeneacetic Acid; α-(2,6-Difluoro-4-methoxyphenyl)acetic Acid; 886498-98-2; DFMPAA; Difluoromethoxyphenylacetic Acid
EINECS	Contact for details

Quality Control

Our 2,6-Difluoro-4-Methoxyphenylacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material is suitable for demanding applications in pharmaceutical and advanced material research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.