Description

2-Fluoro-5-(trifluoromethoxy)phenylacetic acid is a high-purity fluorinated aromatic building block of significant interest in advanced chemical synthesis. This compound is valued for its unique molecular structure, which incorporates both fluorine and trifluoromethoxy substituents to modulate the electronic and steric properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its properties can enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups contribute to improved efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated components for high-performance liquid crystal displays (LCDs).
• Organic Electronics: Employed in the development of novel organic semiconductors and electron-transport materials due to its electron-withdrawing characteristics.
• Advanced Material Science: Acts as a building block for specialty polymers and coatings that require specific chemical resistance and stability.
• Chemical Research & Development: A versatile reagent for academic and industrial research in organofluorine chemistry and method development.

Basic Information

Product Name	2-Fluoro-5-(Trifluoromethoxy)Phenylacetic Acid
CAS No.	886497-98-9
Molecular Formula	C9H6F4O3
Molecular Weight	238.14 g/mol
Synonyms	2-Fluoro-5-(trifluoromethoxy)benzeneacetic acid; [2-Fluoro-5-(trifluoromethoxy)phenyl]acetic acid; α-(2-Fluoro-5-(trifluoromethoxy)phenyl)acetic acid; 2-Fluoro-5-trifluoromethoxyphenylacetic acid; F-TFM-PAA; 886497-98-9; (2-Fluoro-5-(trifluoromethoxy)phenyl)ethanoic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-(trifluoromethoxy)phenylacetic acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure high purity and batch-to-batch consistency. Our standard quality commitment includes identity confirmation by spectroscopic methods (IR, NMR) and purity determination by HPLC. A detailed Certificate of Analysis (COA) documenting all test results is provided with each shipment. Specifications can be developed to meet custom purity requirements for cGMP or other stringent regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.