Description

3-Chloro-5-(Trifluoromethyl)Anisole is a high-purity, multi-functional aromatic building block characterized by its unique trifluoromethyl and chloro substituents. This compound is valued for its role as a critical intermediate in advanced organic synthesis, enabling the introduction of lipophilic and electron-withdrawing groups into target molecules. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in molecules targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic display technologies and organic light-emitting diodes (OLEDs).
• Functional Polymer Monomer: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or unique surface properties.
• Cross-Coupling Reactions: An effective substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions for constructing complex biaryl systems.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries.

Basic Information

Product Name	3-Chloro-5-(Trifluoromethyl)Anisole
CAS No.	886497-07-0
Molecular Formula	C8H6ClF3O
Molecular Weight	210.58 g/mol
Synonyms	1-Chloro-3-methoxy-5-(trifluoromethyl)benzene; 3-Chloro-5-(trifluoromethyl)methoxybenzene; 3-Chloro-α,α,α-trifluoro-5-methoxytoluene; 5-Chloro-3-methoxybenzotrifluoride; 3-Methoxy-5-chlorobenzotrifluoride; Anisole, 3-chloro-5-(trifluoromethyl)-; Benzene, 1-chloro-3-methoxy-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-(Trifluoromethyl)Anisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.