Description

1-(3-Chloro-4-Methyl-Phenyl)-2,2,2-Trifluoro-Ethanone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the trifluoroacetyl group adjacent to a substituted phenyl ring, making it a critical intermediate for constructing complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients, where the introduction of fluorine atoms is a key strategy to modulate biological activity, metabolic stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Active Ingredient Precursor: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological efficacy.
• Ligand and Catalyst Development: Acts as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic electronic materials to alter solubility and electronic properties.
• Custom Synthesis and Contract Manufacturing: A vital building block for fine chemical companies offering bespoke synthesis services for clients in life sciences.
• Academic Research: Utilized in university and institutional labs for methodological studies in fluorination chemistry and heterocycle formation.

Basic Information

Product Name	1-(3-Chloro-4-Methyl-Phenyl)-2,2,2-Trifluoro-Ethanone
CAS No.	886370-18-9
Molecular Formula	C9H6ClF3O
Molecular Weight	222.59 g/mol
Synonyms	3'-Chloro-4'-methyl-2,2,2-trifluoroacetophenone; 2,2,2-Trifluoro-1-(3-chloro-4-methylphenyl)ethanone; 1-(3-Chloro-4-methylphenyl)-2,2,2-trifluoroethan-1-one; 3-Chloro-4-methyl-α,α,α-trifluoroacetophenone; TFAP derivative; Trifluoroacetyl-(3-chloro-4-methyl)benzene
EINECS	Contact for details

Quality Control

Our production of 1-(3-Chloro-4-Methyl-Phenyl)-2,2,2-Trifluoro-Ethanone adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality system is designed to support cGMP and ISO standards for pharmaceutical and fine chemical intermediates, ensuring traceability and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage under an inert atmosphere (e.g., nitrogen) is recommended to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.