Description

1-(3-Ethynylphenyl)-3,3-Dimethylazetidin-2-One is a high-purity, advanced pharmaceutical intermediate featuring a unique azetidinone core linked to an ethynylphenyl moiety. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily needed by research and development teams in the pharmaceutical and biotechnology industries for the development of new therapeutic agents, particularly in areas requiring complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Protease Inhibitor Development: The azetidinone structure is valuable for creating inhibitors of specific enzymes like proteases.
• Chemical Biology Probes: The alkyne (ethynyl) group allows for bioorthogonal conjugation, useful in creating probes for target identification and validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scale-up and cGMP production of investigational new drugs.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and drug discovery methodologies.

Basic Information

Product Name	1-(3-Ethynylphenyl)-3,3-Dimethylazetidin-2-One
CAS No.	886361-64-4
Molecular Formula	C13H13NO
Molecular Weight	199.25 g/mol
Synonyms	3,3-Dimethyl-1-(3-ethynylphenyl)azetidin-2-one; 1-(3-Ethynylphenyl)-3,3-dimethyl-2-azetidinone; Azetidin-2-one, 1-(3-ethynylphenyl)-3,3-dimethyl-; 886361-64-4; 3,3-Dimethyl-1-(3-ethynylphenyl)-2-azetidinone
EINECS	Contact for details

Quality Control

Our 1-(3-Ethynylphenyl)-3,3-Dimethylazetidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.