Description

2,3,4,5,6-Pentafluorophenyl 2-Propanesulfonate is a specialized organofluorine sulfonate ester, serving as a high-value building block and derivatization agent in advanced synthetic chemistry. Its core value lies in the unique reactivity of the pentafluorophenyl (PFP) leaving group, which facilitates efficient nucleophilic substitution reactions under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, particularly for the synthesis of complex molecules, labeling studies, and the development of novel functional materials.

Application

• Pharmaceutical Intermediate: Key reagent for the synthesis of active pharmaceutical ingredients (APIs), especially in nucleoside and nucleotide chemistry.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides, fungicides, and insecticides that require fluorinated aromatic components.
• Proteomics & Bioconjugation: Acts as a versatile linker or activating agent for labeling proteins, peptides, and other biomolecules.
• Polymer & Materials Science: Employed in the synthesis of fluorinated polymers, liquid crystals, and specialty materials with enhanced stability and performance.
• Cross-Coupling Reactions: Serves as an electrophilic partner in palladium-catalyzed cross-coupling reactions to form carbon-heteroatom bonds.
• Analytical Chemistry: Useful as a derivatization agent in chromatography and mass spectrometry for the detection and analysis of complex mixtures.

Basic Information

Product Name	2,3,4,5,6-Pentafluorophenyl 2-Propanesulfonate
CAS No.	886361-27-9
Molecular Formula	C9H5F5O3S
Molecular Weight	288.19 g/mol
Synonyms	Pentafluorophenyl 2-Propanesulfonate; 2-Propanesulfonic Acid Pentafluorophenyl Ester; PFP-Propylsulfonate; 1-Methylethylsulfonyloxy Pentafluorobenzene; 2,3,4,5,6-Pentafluorophenyl Isopropyl Sulfonate; Pentafluorophenyl Isopropylsulfonate; PFP-OSO2Pr
EINECS	Contact for details

Quality Control

Our 2,3,4,5,6-Pentafluorophenyl 2-Propanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.