Description

3-[4-(Methoxycarbonyl)Phenyl]-3-[(2,2,2-Trifluoroacetyl)Amino]Propanoic Acid is a high-purity, non-natural amino acid derivative characterized by its trifluoroacetyl-protected amine and carboxylic acid functionalities. This compound is a critical advanced pharmaceutical intermediate (API) designed for the synthesis of complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, including protease inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting enzymatic pathways.
• Protease Inhibitor Research: Serves as a core structural component in the design and development of novel protease inhibitor compounds for antiviral and anticancer applications.
• Peptidomimetic Chemistry: Used in the construction of peptidomimetics, where its structure helps mimic peptide bonds while offering enhanced metabolic stability.
• Medicinal Chemistry & Drug Discovery: Employed in lead optimization and structure-activity relationship (SAR) studies to improve drug potency and selectivity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions.
• Bioconjugation & Probe Development: The carboxylic acid group allows for conjugation to other molecules, making it useful for creating fluorescent probes or affinity labels for biochemical assays.

Basic Information

Product Name	3-[4-(Methoxycarbonyl)Phenyl]-3-[(2,2,2-Trifluoroacetyl)Amino]Propanoic Acid
CAS No.	886360-56-1
Molecular Formula	C13H12F3NO5
Molecular Weight	319.24 g/mol
Synonyms	3-[(2,2,2-Trifluoroacetyl)amino]-3-[4-(methoxycarbonyl)phenyl]propanoic acid; 3-Amino-3-[4-(methoxycarbonyl)phenyl]propanoic acid N-trifluoroacetate; Methyl 4-[1-[(2,2,2-trifluoroacetyl)amino]-2-carboxyethyl]benzoate; β-[(Trifluoroacetyl)amino]-β-[4-(methoxycarbonyl)phenyl]propionic Acid; TFAA-protected β-amino acid derivative; (3R/S)-3-[4-(Methoxycarbonyl)phenyl]-3-[(2,2,2-trifluoroacetyl)amino]propanoic acid (racemic mixture)
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical R&D and pre-clinical development. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and mass spectrometry. While not necessarily manufactured under full cGMP, our processes are designed to meet the exacting standards required for non-clinical and early-phase clinical material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions or inert atmosphere to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation (if applicable)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.