Description

2-Hydroxy-5-Nitrophenylacetylene is a specialized aromatic acetylene derivative featuring both a phenolic hydroxyl and a nitro substituent, making it a versatile building block for advanced organic synthesis. This compound is valued for its ability to participate in click chemistry reactions, such as the copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling the construction of complex molecular architectures. It is primarily sought by researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries for developing novel active ingredients, polymers, and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting specific enzyme inhibition or requiring complex heterocyclic cores.
• Agrochemical Research: Used in creating new active ingredients for crop protection agents, leveraging its structural motifs for bioactivity.
• Polymer & Material Science: Acts as a monomer or cross-linking agent in the development of specialty polymers, dendrimers, and smart materials via its acetylene functionality.
• Click Chemistry: An ideal substrate for Huisgen 1,3-dipolar cycloaddition and other metal-catalyzed coupling reactions to create triazole-linked compounds.
• Ligand & Catalyst Development: Employed in synthesizing novel chelating ligands for catalysis and metal-organic frameworks (MOFs).
• Dye & Pigment Synthesis: Functions as an intermediate for producing advanced organic dyes and pigments with specific optical properties.

Basic Information

Product Name	2-Hydroxy-5-Nitrophenylacetylene
CAS No.	885951-98-4
Molecular Formula	C8H5NO3
Molecular Weight	163.13 g/mol
Synonyms	5-Nitro-2-ethynylphenol; 2-Ethynyl-5-nitrophenol; 1-Hydroxy-4-nitro-2-ethynylbenzene; (2-Hydroxy-5-nitrophenyl)acetylene; 2-(Hydroxy)-5-nitrophenylacetylene; 5-Nitrosalicylaldehyde alkyne derivative; Phenol, 2-ethynyl-5-nitro-
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-5-Nitrophenylacetylene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.