Description

Fmoc-1-Amino-1-Cyclobutanecarboxylic Acid is a high-purity, non-proteinogenic amino acid derivative designed for advanced peptide synthesis. This compound is a critical building block for introducing the constrained 1-amino-1-cyclobutanecarboxylic acid scaffold into peptide chains, which is essential for modulating peptide conformation, stability, and biological activity. It is primarily utilized by pharmaceutical researchers, medicinal chemists, and CROs/CDMOs engaged in the development of novel therapeutic peptides, peptidomimetics, and PROTACs.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the sequential assembly of peptides using Fmoc/t-Bu chemistry.
• Medicinal Chemistry & Drug Discovery: Used to incorporate the rigid, four-membered cyclobutane ring into peptide backbones to enhance metabolic stability, improve receptor selectivity, and explore structure-activity relationships (SAR).
• Peptidomimetic Design: Serves as a key scaffold for creating conformationally restricted peptidomimetics that mimic natural peptides but with improved pharmacological properties.
• PROTAC & Bifunctional Molecule Synthesis: Employed in the construction of linkers or protein-binding motifs for targeted protein degradation technologies.
• Bioconjugation: Can be used to introduce unique, functionalized amino acid sites into proteins or other biomolecules for labeling or cross-linking.
• Academic Research: A valuable tool for studying peptide folding, protein-protein interactions, and the biophysical impact of ring strain in polypeptide chains.

Basic Information

Product Name	Fmoc-1-Amino-1-Cyclobutanecarboxylic Acid
CAS No.	885951-77-9
Molecular Formula	C₂₀H₁₉NO₄
Molecular Weight	337.37 g/mol
Synonyms	Fmoc-1-Acb-OH; Fmoc-Amino-cyclobutanecarboxylic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-amino-1-cyclobutanecarboxylic Acid; 1-[(9-Fluorenylmethoxycarbonyl)amino]cyclobutanecarboxylic Acid; Fmoc-ACBC-OH; Fmoc-1-Amino-cyclobutane-1-carboxylic Acid; (1-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)cyclobutane-1-carboxylic Acid
EINECS	Contact for details

Quality Control

Our Fmoc-1-Amino-1-Cyclobutanecarboxylic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, meeting the exacting standards required for pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant industry guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.