Description

[3-[3,5-Bis(Trifluoromethyl)Phenoxy]Phenyl]Sulfonyl Chloride is a high-value, multi-fluorinated aromatic sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the unique reactivity of the sulfonyl chloride group and the electron-withdrawing properties of the bis(trifluoromethyl)phenoxy moiety, enabling the construction of complex molecules with enhanced stability and specific functionalities. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for creating novel sulfonamides, sulfonate esters, and other active intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting metabolic and central nervous system disorders.
• Agrochemical Synthesis: Used to develop novel herbicides, fungicides, and insecticides where the trifluoromethyl groups confer improved lipophilicity and metabolic stability.
• Material Science Research: Building block for creating specialty polymers, liquid crystals, and advanced organic electronic materials due to its aromatic and fluorinated structure.
• Chemical Biology Probes: Employed in the design of activity-based probes and covalent inhibitors for studying enzyme function and drug discovery.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	[3-[3,5-Bis(Trifluoromethyl)Phenoxy]Phenyl]Sulfonyl Chloride
CAS No.	885950-87-8
Molecular Formula	C15H6ClF6O3S
Molecular Weight	448.71 g/mol
Synonyms	3-[3,5-Bis(trifluoromethyl)phenoxy]benzenesulfonyl chloride; 1-Chlorosulfonyl-3-[3,5-bis(trifluoromethyl)phenoxy]benzene; m-[3,5-Bis(trifluoromethyl)phenoxy]benzenesulfonyl chloride; 3-(3,5-Bis(trifluoromethyl)phenoxy)phenylsulfonyl chloride; [3-(3,5-Bis(trifluoromethyl)phenoxy)phenyl]sulfonyl chloride
EINECS	Contact for details

Quality Control

Our [3-[3,5-Bis(Trifluoromethyl)Phenoxy]Phenyl]Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your quality assurance and regulatory documentation needs for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis of the sulfonyl chloride group. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.