Description

2,3,4,5,6-Pentafluorophenyl 2,4,6-Trimethylbenzenesulfonate is a specialized sulfonate ester derivative, valued for its role as a versatile building block and reagent in advanced synthetic chemistry. Its molecular structure, featuring both a perfluorinated phenyl group and a mesitylenesulfonyl moiety, makes it particularly useful for introducing fluorinated aromatic systems and acting as a leaving group in nucleophilic substitution reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, where it facilitates the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, including protease inhibitors and kinase modulators.
• Agrochemical Synthesis: Used in creating advanced, fluorinated pesticides and herbicides with enhanced biological activity and environmental stability.
• Materials Science Research: Serves as a precursor for fluorinated polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: Acts as an electrophilic partner in Suzuki-Miyaura and other metal-catalyzed cross-coupling reactions to form biaryl structures.
• Proteomics & Bioconjugation: Utilized as a labeling or activating reagent for modifying peptides, proteins, and other biomolecules.
• Organic Synthesis Reagent: Functions as a robust sulfonylation agent or a protected, activated alcohol derivative in multi-step synthetic routes.

Basic Information

Product Name	2,3,4,5,6-Pentafluorophenyl 2,4,6-Trimethylbenzenesulfonate
CAS No.	885950-62-9
Molecular Formula	C15H11F5O3S
Molecular Weight	366.31 g/mol
Synonyms	Pentafluorophenyl Mesitylenesulfonate; Mesitylenesulfonic Acid Pentafluorophenyl Ester; 2,4,6-Trimethylbenzenesulfonic Acid 2,3,4,5,6-Pentafluorophenyl Ester; 2,3,4,5,6-Pentafluorophenyl Mesitylenesulfonate; PFPMes; PFP-Mesylate; Pentafluorophenyl 2,4,6-Trimethylbenzenesulfonate
EINECS	Contact for details

Quality Control

Our production of 2,3,4,5,6-Pentafluorophenyl 2,4,6-Trimethylbenzenesulfonate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.