Description

Phenyl-[(S)-1,1-Spirobiindane-7,7-Diyl]-Phosphite, (11As)-(-)-10,11,12,13-Tetrahydrodiindeno[7,1-De:1μ,7μ-Fg][1,3,2]Dioxaphosphocin-5-Phenoxy is a high-value, chiral phosphite ligand with a unique spirobiindane backbone. This compound is critically important as an asymmetric catalyst precursor in enantioselective synthesis, enabling the production of chiral molecules with high optical purity. It is primarily needed by pharmaceutical R&D and fine chemical manufacturing sectors for developing advanced active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Asymmetric Hydrogenation: As a key ligand for transition metal catalysts (e.g., Rh, Ru) in the enantioselective reduction of prochiral olefins, ketones, and imines.
• Pharmaceutical Intermediate Synthesis: For the production of chiral building blocks and advanced intermediates in the synthesis of complex drug molecules.
• Asymmetric C-C Bond Formation: In catalytic reactions such as allylic alkylation and conjugate addition to achieve high enantiomeric excess (ee).
• Agrochemical Synthesis: In the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial Research: As a sophisticated tool for methodological development in organic and organometallic chemistry.
• Material Science: Potential use in the synthesis of chiral polymers or as a modifier for asymmetric surfaces.

Basic Information

Product Name	Phenyl-[(S)-1,1-Spirobiindane-7,7-Diyl]-Phosphite, (11As)-(-)-10,11,12,13-Tetrahydrodiindeno[7,1-De:1μ,7μ-Fg][1,3,2]Dioxaphosphocin-5-Phenoxy
CAS No.	885701-71-3
Molecular Formula	C31H23O3P
Molecular Weight	474.48 g/mol
Synonyms	(S)-(-)-Phenylspirobiindane phosphite; (S)-SIPHOS-PE; (S)-2,2',3,3'-Tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diyl phenyl phosphite; (11aS)-5-Phenoxy-10,11,12,13-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin; (S)-Spiro Phosphite Ligand; (S)-SPIROP; Chiral Spirobiindane Phosphite Ligand
EINECS	Contact for details

Quality Control

Our production of this advanced chiral ligand adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for catalytic performance. Each lot is characterized by NMR, HPLC, and optical rotation analysis to confirm identity, chemical purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere such as argon or nitrogen to prevent oxidation and moisture absorption. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Specific Optical Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.