Description

Leucine, 4-Fluoro-, Ethyl Ester is a fluorinated derivative of the amino acid leucine, specifically modified as an ethyl ester. This specialized building block is crucial for introducing fluorine atoms into peptide backbones, a strategy used to enhance metabolic stability, bioavailability, and binding affinity in bioactive molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel fluorinated peptides, peptidomimetics, and other advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of fluorinated peptide-based drugs, including protease inhibitors and hormone analogs.
• Peptidomimetic Design: Used to create stable peptide mimics with improved pharmacological properties by incorporating fluorine at the 4-position of leucine.
• Agrochemical Research: Serves as a building block in the synthesis of novel fluorinated bioactive compounds for crop protection.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Process Chemistry: Used in scale-up and optimization for the commercial production of fluorinated active pharmaceutical ingredients (APIs).
• Academic Research: A valuable reagent for universities and research institutes exploring the effects of fluorine substitution on peptide structure and function.

Basic Information

Product Name	Leucine, 4-Fluoro-, Ethyl Ester
CAS No.	885498-60-2
Molecular Formula	C8H16FNO2
Molecular Weight	177.22 g/mol
Synonyms	4-Fluoro-L-leucine ethyl ester; Ethyl 4-fluoro-L-leucinate; L-Leucine, 4-fluoro-, ethyl ester; (S)-Ethyl 2-amino-4-fluoropentanoate; 4-Fluoro-leucine ethyl ester; 4-Fluoro-leucine ethylester; Ethyl (2S)-2-amino-4-fluoropentanoate
EINECS	Contact for details

Quality Control

Our Leucine, 4-Fluoro-, Ethyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (HPLC), enantiomeric excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.