Description

β-Amyloid (11-22) CAS NO 885323-98-8 is a synthetic peptide fragment corresponding to amino acid residues 11 through 22 of the human amyloid-beta protein. This specific sequence is a critical research tool for studying the aggregation mechanisms and neurotoxic properties associated with Alzheimer's disease pathology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on neurodegenerative disorders and therapeutic discovery.

Application

• Biomedical Research: Fundamental studies on amyloid-beta peptide aggregation kinetics, fibril formation, and structure-activity relationships.
• Drug Discovery & Screening: Serving as a key antigen or target in high-throughput assays to identify and evaluate potential inhibitors of amyloid aggregation.
• Antibody Development & Validation: Used for the production, characterization, and specificity testing of antibodies targeting the mid-region of the amyloid-beta protein.
• Diagnostic Assay Development: Acting as a critical component in the calibration and validation of immunoassays (e.g., ELISA) for detecting amyloid-beta variants.
• Toxicology Studies: Investigating the cellular and molecular mechanisms of peptide-induced cytotoxicity in neuronal cell culture models.
• Biophysical Characterization: Employed in techniques such as NMR, CD spectroscopy, and electron microscopy to elucidate peptide conformation and assembly.

Basic Information

Product Name	β-Amyloid (11-22)
CAS No.	885323-98-8
Molecular Formula	C58H89N17O19S
Molecular Weight	1352.5 g/mol
Synonyms	Amyloid β-Protein (11-22); Aβ (11-22); β-Amyloid (11-22) peptide; Amyloid β-Peptide (11-22); H2N-EVHHQKLVFFA-COOH; EVHHQKLVFFA; Aß11-22; Human Amyloid β-Peptide 11-22 Fragment
EINECS	Contact for details

Quality Control

Every batch of β-Amyloid (11-22) is produced and analyzed under stringent quality management protocols. Our products undergo rigorous purity verification using advanced analytical techniques, including HPLC and mass spectrometry, to ensure batch-to-batch consistency and reliability for sensitive research applications. Certificates of Analysis (COA) detailing purity, identity, and peptide content are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This peptide is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture uptake. Aliquot into single-use vials after reconstitution to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70%
Molecular Weight	1352.5 ± 2 Da
Solubility	Soluble in water, DMSO, or dilute acetic acid
Single Peak on HPLC	Present

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.