Description

1-Fmoc-4-Carboxymethylene-Piperidine is a key, high-purity synthetic building block designed for advanced organic synthesis and pharmaceutical research. This compound is specifically engineered for the efficient construction of complex molecular architectures, offering a protected amine and a versatile carboxylic acid handle. It is an essential intermediate for medicinal chemists and process development scientists working in drug discovery and development, particularly for creating peptide mimetics and other bioactive molecules. The product is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency and reliability.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Peptidomimetic Synthesis: Used to introduce constrained piperidine scaffolds and Fmoc-protected amine functionalities into peptide analogs.
• Combinatorial Chemistry: Serves as a versatile monomer in solid-phase and solution-phase library synthesis for high-throughput screening.
• Chemical Biology Probes: Employed in the development of molecular probes and tools for studying biological pathways and target engagement.
• Process Chemistry: Utilized in route scouting and optimization for the scalable production of complex target molecules.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	1-Fmoc-4-Carboxymethylene-Piperidine
CAS No.	885274-82-8
Molecular Formula	C23H23NO4
Molecular Weight	377.44 g/mol
Synonyms	1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(carboxymethyl)piperidine; 4-(Carboxymethyl)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]piperidine; 1-Fmoc-4-(carboxymethyl)piperidine; Fmoc-4-Cmp-OH; 4-Carboxymethyl-1-Fmoc-piperidine; Piperidine, 4-(carboxymethyl)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]-; 1-N-Fmoc-4-carboxymethylpiperidine
EINECS	Contact for details

Quality Control

Every batch of 1-Fmoc-4-Carboxymethylene-Piperidine is manufactured under strict quality management systems and undergoes comprehensive analytical testing. Our products are guaranteed to meet the high-purity standards required for research and pharmaceutical development. A detailed Certificate of Analysis (COA) providing results for identity, purity, and related substances is provided with each shipment to ensure full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.