Description

Ethyl 3-(2-Carboxy-Vinyl)-5-Fluoro-1H-Indole-2-Carboxylate is a high-purity fluorinated indole derivative, a crucial advanced pharmaceutical intermediate. Its molecular structure makes it a key building block for synthesizing complex active pharmaceutical ingredients (APIs) with targeted therapeutic properties. This compound is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug molecules, especially those containing a fluorinated indole scaffold.
• Oncology Research: Used in the research and development of potential anti-cancer agents, where the fluorine atom and indole core can enhance bioavailability and receptor binding.
• CNS Drug Development: Applied in creating compounds for neurological and psychiatric disorders, leveraging the indole structure common in many neuroactive substances.
• Chemical Synthesis Building Block: Provides a versatile vinyl and ester-functionalized template for further derivatization and coupling reactions in medicinal chemistry.
• Process Development & Scale-Up: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for process optimization and commercial-scale API manufacturing.
• Academic & Industrial R&D: Utilized in research laboratories for exploring new chemical entities and structure-activity relationships (SAR).

Basic Information

Item	Details
Product Name	Ethyl 3-(2-Carboxy-Vinyl)-5-Fluoro-1H-Indole-2-Carboxylate
CAS No.	885273-65-4
Molecular Formula	C₁₄H₁₂FNO₄
Molecular Weight	277.25 g/mol
Synonyms	5-Fluoro-3-(2-carboxyethenyl)-1H-indole-2-carboxylic acid ethyl ester; Ethyl 5-fluoro-3-[(1E)-2-carboxyethenyl]-1H-indole-2-carboxylate; (E)-Ethyl 3-(2-carboxyvinyl)-5-fluoro-1H-indole-2-carboxylate; 5-Fluoroindole-2,3-dicarboxylic acid 2-ethyl ester 3-acrylic acid; 885273-65-4; 5-Fluoro-3-(2-carboxyvinyl)-1H-indole-2-carboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 3-(2-Carboxy-Vinyl)-5-Fluoro-1H-Indole-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.